Owl Drug Co. is an elevated brew pub serving American comfort food, sophisticated cocktails and 28 rotating tap handles. Stop in and raise a glass to downtown San Diego's only venue to offer karaoke every Friday and Saturday night, as well as during bottomless mimosa brunch on Sunday beginning mid February 2019. Featuring an award-winning brewhouse onsite, Owl Drug Co. serves up craft beers on tap while providing an environment where both residents and tourists feel welcome.



Every Friday & Saturday night
+ sunday brunch


A social eating experience. An unconventional way to meet new people... whether sitting at a communal table or at the bar, always believe in sharing. Most of the menu is designed for sharing. We use food and drink to connect people.

Before there were gastropubs, there was just pubs. Well, we’re just a pub. A pub that has been twisted and elevated. Strictly Americana but traveling coast to coast (okay... and maybe a little bit south of our border). We get bored easily, so don’t surprised if something comes off the menu and replaced with another pub favorite.

Relax, be yourself (no expectations or pretensions) and enjoy new people, appreciate your beverage (from our brewery, wine list or array of handcrafted cocktails); eat slow; be adventurous; and live the Owl Life.

— Jason Kong, your host and proprietor


The History


Built in 1908.

Built in 1908 and designated a Historical Building in 2001, the structure was dubbed the Colonel Fletcher Building after famed San Diego real estate developer and California State Senator, Colonel Ed Fletcher. The first floor was originally home to Owl Drug Company, which then featured an apothecary, cafe and bowling lanes.


Established in 2019.

Opened in January 2019, the space anchors the Northeast corner of 6th Street and Broadway Ave. The venue boasts a new (old) name, which serves as a homage to the building's history. The brew pub invites guests to enjoy a menu of mostly shareable pub food, such as pizzas, classic dips and hot sandwiches, which pair well with their wide variety of 28 draft beers and craft cocktails.